That’s what researchers at Bioprocessing Technology Institute (A*STAR – Agency for Science, Technology and Research) found when they scaled up their CHO-based alpha-1-antitrypsin (A1AT) process, a protein in high demand for treating a rare, life-threatening lung condition. They didn’t redesign their process. They didn’t battle shear stress. They moved from their shake flask to a Kuhner SB10-X Orbital Shaken Bioreactor, and their cells barely noticed the difference:
- Comparable VCD profiles
- Comparable specific productivity (9.6-12pg/cell/day)
- Same gentle, bubble-free surface aeration
Read the paper to discover how the SB10-X supported this scale-up with minimal process change
To learn more about Kuhner’s Orbital Shaken Bioreactors contact Capella Science today on (02) 9575 7512 or sales@capellascience.com.au. For research use only and not for use in diagnostic procedures
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